HIV Infection: Immunopathogenesis and Risk Factor to Fishermen

Immunopathogenesis of HIV infection.

Progression of HIV infection is largely dependent on the interaction between the viral factors and host factors. HIV primarily infects the CD4 lymphocytes in the body. It brings about the destruction of CD4 cells through multiple mechanisms including apoptosis. The loss of CD4 cell population ultimately leads to the inability of infected person to deal with opportunistic organisms. Host genetic...

Genetic correlates influencing immunopathogenesis of HIV infection

Variability to HIV infection, its progression as well as responsiveness to antiretroviral therapy (ART) is observed among individuals including viraemia controllers or exposed uninfected, rapid versus slow progressors and ART responders compared to non responders. This differential responsiveness/vulnerability to HIV-1 is governed by multiple host genetic factors that include HLA, cytokines, ch...

On the Immunopathogenesis of Hiv Infection

HIV infection as a risk factor for septic arthritis.

We prospectively studied the demographics, the clinical and diagnostic features, the HIV-1 serostatus and the therapeutic response for all new patients with septic arthritis (SA) admitted to the Department of Internal Medicine of the Centre Hospitalier de Kigali, Rwanda, over a 19 month period. SA was diagnosed in 24 patients (10 male, 14 female), of whom 19 (79%) were HIV-1 seropositive (HIVpo...

Food Insecurity—A Risk Factor for HIV Infection

HIV and nutrition are linked in at least two important ways. First, the nutritional consequences of HIV have been obvious from the earliest reports of the epidemic in Africa. Patients suffering from the infection in Uganda were said to have " slim disease " [1]. More than 25 years later, we are still grappling with the mechanisms by which HIV causes wasting and defining the macronutrient and mi...